产品货号：
Z22643
中文名称：
p16INK4a/CDKN2A抗体
英文名称：
Anti-p16INK4a/CDKN2A Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-p16INK4a/CDKN2A Antibody |
| 指标别名 | ARF;ARF;CDKN2A;CDK4 inhibitor p16 INK4;CDK4 inhibitor p16INK4;CDK4I;CDKN2;CDKN2A;CMM2;INK4;INK4a;MLM;MTS 1;MTS1;Multiple tumor suppressor 1;P16;p16 INK4;p16 INK4a;p16INK4;p16INK4a;P16-INK4A;TP16 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | CDKN2A |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Anti-CDKN2A antibody was raised against a peptide corresponding to 18 amino acids near the amino terminus of human CDKN2A.The immunogen is located within the first 50 amino acids of CDKN2A. |
| 计算分子量 | 17kDa |
| 成分 | CDKN2A Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | CDKN2A Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | The CDKN2A locus gives rise to 2 distinct transcripts from different promoters.The transcripts have been designated p16(INK4A) and p14(ARF).This chromosomal region undergoes a number of inversions,translocations,heterozygous deletions,and homozygous deletions in a variety of malignant cell lines including those from glioma,non-small cell lung cancer,leukemia,and melanoma.Deletion of the region containing CDKN2A is found in more than half of all melanoma cell lines.Conversely,transfection of CDKN2A suppressed the growth of two independent mesothelioma cell lines,suggesting that inactivation of the CDKN2 gene is an essential step in the etiology of malignant mesotheliomas.CDKN2A induces a G1 cell cycle arrest by inhibiting the phosphorylation of the Rb protein by the cyclin-dependent kinases CDK4 and CDK6.CDKN2A is expressed as at least three distinct isoforms. |
| Uniprot ID | P42771 |
| 基因名全称 | Cyclin-dependent kinase inhibitor 2A (melanoma,p16,inhibits CDK4) |
| 蛋白名全称 | Cyclin-dependent kinase inhibitor 2A (melanoma,p16,inhibits CDK4) |
| 推荐稀释比 | WB:1 ～ 4μg/mL;IHC:5 ～ 10μg/mL;IF:20μg/mL.Antibody validated:Western Blot in human and mouse samples;Immunohistochemistry in human and rat samples;Immunofluorescence in human and rat samples.All other applications and species not yet tested. |
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